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KMID : 0385020020180030114
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Korean Journal of Laboratory Animal Science
2002 Volume.18 No. 3 p.114 ~ p.119
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Fine Mapping of the Circling (cir) Gene on Distal Mouse Chromosome 9
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Lee, Jeong Woong
Cho, Kyoung In/Choe, Nonghoon/Kim Kil-Soo/Lee, Eun-Ju/Kim, Myoung-Ok/Kim, Sung-Hyun
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Abstract
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cir mice were recorded to display profound deafness and a head-tossing and bidirectional circling behavior, showing an autosomal recessive mode of inheritance. In addition, the histological examination of inner ears revealed that the region around organ of Corti, spiral ganglion neurons and outer hair cells showed definite abnormality. On the other hand, a genetic linkage map was constructed in an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mit116/D9Mit15 and D9Mit38 on the mouse chromosome 9. Estimated distances between cir and D9Mit116, and between cir and D9Mit38 are 0.70±0.40 and 0.23± cM, respectively. The gene in order was defined as follows: centromere-D9Mit182- D9Mit51/ D9Mit791 D9Mit310- D9Mit212/ D9Mit184- D9Mit116/ D9Mit15- cir- D9Mit38- D9Mit20- D9Mit243- D9Mit16- D9Mit55/ D9Mit125- D9Mit281. he distal portion of mouse Chr 9 encompassing the cir region was shared a conserved linkage homology with human chromosome 3p21. Since the human chromosome 3p21 was the region of DFNB6 deafness, cir mice were a valuable the animal models for DFNB6 deafness in human.
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